The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease.

Confirmation of O 2 -• production There was a highly significant positive correlation (r = 0.94, p = 0.006) between chemiluminescence and XO concentration in the presence of a constant concentration of 100 μM xanthine ( Fig. 1 A). 50 U/ml superoxide dismutase (SOD) completely abolished chemiluminescence in the presence of 100 μM xanthine and 10 mU/ml XO (p < 0.001), indicating that O 2 -• was the principal active molecule generated under the conditions of these experiments ( Fig. 1 B).

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Blood from healthy donors also demonstrated concentration-dependent inhibition of WBA in response to X/XO although this failed to reach statistical significance (n = 4; Fig. 2 C), while addition of XO alone did not affect WBA to either agonist (data not shown).

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