Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.

Functional rescue of viability in the presence of CA-074-Me and pepstatin A was assessed at 24 hours following treament, and pepstatin A was observed to rescue viability across a titrated dose range for all compounds, while CA-074-Me had a lesser effect, though the observed differences did not reach statistical significance (Figure 5 D).

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