Anti-TNF-alpha-adalimumab therapy is associated with persistent improvement of endothelial function without progression of carotid intima-media wall thickness in patients with rheumatoid arthritis refractory to conventional therapy.

In keeping with that, although in our study reduction of blood pressure following 12-month adalimumab therapy did not reach statistical significance, it is remarkable to see that both the mean systolic and diastolic blood pressure were reduced in adalimumab-treated patients when compared with baseline results of blood pressure obtained at the onset of this biologic therapy.

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