Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.

After orthologous complementation, among the highly significant candidate genes were, for example, PAI3 (essential Proteinase A inhibitor) in S. cerevisiae , hcf-1 (human host cell factor (HCF-1) homolog) in C. elegans , CG7333 (an organic cation transmembrane transporter) in D. melanogaster , Raf1 (MAP kinase kinase kinase) in Mus musculus , and ACD (involved in telomere maintenance and meiosis) in humans.

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Although no homologous group was significant at False Discovery Rate (FDR)<0.05 (which appears to be too strict for comparisons across multiple species), by the more relaxed criterion of having a binomial p-value<0.05, four homologous groups were nominally significant: CAB39 , the genes encoding 14-3-3 proteins, sirtuins, and AHCY encoding S-adenosylhomocysteinase.

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