Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.

Neurofilament H expression was slightly reduced on day 2 after footshock ( Figure 3C: t (10) = 2.422, p = 0.035), remained unchanged on day 28 but showed a trend towards a reduction on day 60 after footshock ( Figure 3C: t (21) = 1.873, p = 0.075), while both MAP-2 and GFAP expression levels were not significantly altered at any of the three time points analyzed ( Figure 3D, E , see Table 1 for summary of all tested proteins).

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In addition to synaptic protein loss, we detected a significant reduction of the neuronally expressed neurofilament H on day 2 and a statistical trend in neurofilament H reduction on day 60 after footshock in the hippocampus of traumatized mice.

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