A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.

PLoS One · 2012 · PMC3419214 · PMID 22905266

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a clear trendp = 0.06so close (0.05 < p ≤ 0.1)

While the association with violence in the pairwise comparison between the Met homozygous and Val homozygous groups did not reach our threshold of statistical significance, a clear trend was identified in the anticipated direction (DOR = 1.63; 95% CI = 0.94–2.82; z = 1.55, p = 0.06).

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a marginal trendno p-value reported

There was a marginal trend for higher violence risk in individuals with the Met allele in samples with higher rates of lifetime drug (non-alcohol) abuse.

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marginally significantno p-value reported

Using outcome data for all participants, a marginally significant trend was found such that in samples with higher rates of lifetime drug (non-alcohol) abuse, individuals with the Met allele were at higher risk of violence ( β = 0.02, p = 0.09).

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