Quantification of GFAP staining in cortical layers showed a trend of higher expression of GFAP in old ApoE−/− mice when compared to young ApoE−/− mice (12.0 ± 0.05 A.U. vs. 8.51 ± 2.35 A.U., respectively) and a significant increase of GFAP when compared to young and old WT mice (12.0 ± 0.05 A.U. vs. 4.60 ± 2.17 A.U., 12.0 ± 0.05 A.U. vs. 5.54 ± 0.58 A.U, respectively, Figure 4 B) AQP4, a water channel present in astrocyte endfeet, was present in close contact to the blood vessels (Figure 4 C).
← all excerpts
Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit.
1
—
—