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Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex.

PLoS One · 2012 · PMC3420872 · PMID 22916276

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In the ventral prelimbic cortex, the Fos response in cocaine withdrawn rats was also lower (34% reduction) but did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.