a strong trendp = 0.053
The bivariate regression analysis to address the strength of the relationship between the maternal plasma variables and the infants’ development test scores, with no consideration of confounding variables, revealed significant correlations between the maternal plasma free choline (B = 4.589, SE = 1.932, p = 0.019) and betaine (B = 6.366, SE = 1.723, p = 0.0003), and a strong trend for dimethylglycine (B = 2.134, SE = 1.095, p = 0.053) at 16 weeks of gestation and the infants’ cognitive developmental scores ( Table 4 ).