Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.

PLoS One · 2012 · PMC3427336 · PMID 22937066

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Interestingly, two of those data sets showed a trend of gradual decrease of KLF4 mRNA expression with liver disease progression: Wurmbach’s data set ( GSE14520 ) showed consistent reduction of KLF4 mRNA in samples from tissues of normal, cirrhosis, dysplasia, to HCC in a stepwise manner [32] .

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