Betaglycan (TβRIII) is expressed in the thymus and regulates T cell development by protecting thymocytes from apoptosis.

In accordance, MFI for active caspase 3 also showed an increase in this apoptotic mediator in DP and DN subpopulations, although the latter did not reach statistical significance, suggesting that DP thymocytes are more susceptible to die in TβRIII −/− fetal thymi ( Figure 5A ).

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