Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD.

In fact, when participants with MMSE ≥ 26 were excluded, levels of A β 1-40 and A β 1-42 were lower in severely affected patients (MMSE ≤ 21, n = 5) than in moderately affected patients (MMSE 22–25, n = 12), although the differences did not reach statistical significance (data not shown).

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The consensus arising from these papers is congruent with studies in an AD mouse model (tg 2576), which have shown highly significant decreases in plasma A β 1-40 and A β 1-42 linked to the marked accumulation of A β in the brain that begins in these animals at 6–9 months of age [ 22 ].

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