Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma.

In particular, in 10-fold cross-validation experiments on held-out genes, we obtained a mean Spearman rank correlation between predicted and measured gene expression changes of 0.174, a modest but highly significant result ( P <2e−16), shown in Figure 2A .

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We observe that proneural patients with high miR-132 model coefficient showed a trend toward better survival ( Supplementary Figure 6B ), recovering a pattern observed in the training and test TCGA data sets, though the survival difference was not statistically significant.

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