Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.

We found that, compared to Msh2 +/+ mice, mAb5374 staining was reduced in both Msh2Δ / Δ (p<0.01) and Msh2Δ /− (p<0.001) mice as well as in Msh2 −/− mice as predicted (p<0.05) ( Figure 4A, B ), although the difference in staining intensities in Msh2 +/− and Msh2Δ /− striata did not reach statistical significance (p = 0.18).

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