β-hairpin forms by rolling up from C-terminal: topological guidance of early folding dynamics.

Moreover, turn formation at Thr8 and Trp9 appears to play a central role in the temporal progression of turn structures when the peptide is relatively extended, and a clear trend emerges in the occurrence of turns leading up to turn formation closer to the NT region, although this progression is generally masked by intermittency ( Figure 1d ); note that, in comparison, such a turn progression is completely obscured if one restricts oneself to analyses in terms of RMSD and R g alone ( Figure 1d ).

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