Coincidentally, the Michael J Fox foundation recently posted online data detailing phenotypic testing of their LRRK2 KO model being characterized at Wil Research and this data showed a trend for enhanced rotarod performance in 4 month old KO mice compared with WT controls http://www.pdonlineresearch.org/sites/default/files/MJFF%20Animal%20Models%20Data%20-%20Oct%2031.pdf ).
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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
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The borderline significance of the genotype effect was due to high variability in this behavior at 7-months (Figure 3 E).