Our model allows some estimate of the relative contribution of these effects, although this is not fully significant since they are not additive: We built survival curves for the highest force ( Figure 4D ) with the following assumptions: i) force sharing, rebinding and bond strengthening, ii) rebinding and bond strengthening, iii) force sharing and bond strengthening, and iv) force sharing and rebinding.
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Quantitative modeling assesses the contribution of bond strengthening, rebinding and force sharing to the avidity of biomolecule interactions.
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