Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

8 a), and of another 13 metabolites, which narrowly missed the p < 0.05 cutoff (e.g., hippurate, myo-inositol, homocarnosine, phosphopantetheine with p = 0.0535, 0.0538, 0.0618, and 0.066, respectively) or with trends approaching significance (0.05 < p < 0.10) (Fig. 8 b).

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