ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer.

This correlation was less strong but still highly significant in the ER+ve population only (blue symbol, Figure 2a ; Spearman R = 0.53; P < 0.0001).

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Considering only the ER+ve HER2-ve cases, a test for trend showed a nonsignificant trend to a difference in TTR between the quartiles of RNA levels for ER and HER2 (Figure 5c , p trend = 0.058; and Figure 5d , p trend = 0.069, respectively).

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The lowest quartile of HER2 levels showed a trend to shortest TTR at 5 and 10 years (HR (95% CI), 0.83 (0.51 to 1.36) and 0.76 (0.55 to 1.06), respectively).

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