Ten-m3 is required for the development of topography in the ipsilateral retinocollicular pathway.

Quantitative analysis confirmed a highly significant interaction between age and TZ size ( Fig. 2L ; ANOVA, F(4,18) = 298.03. p<0.001).

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While the length or width of the TZ expressed as a percentage of the RC (contralateral WT: 9.8±1.7%, contralateral KO: 14.6±1.4%, mean ± se, n = 6, multi-factorial ANOVA F(1,10) = 4.663, p = 0.056; ipsilateral WT: 7.2±0.6%, ipsilateral KO: 9.5±2.3%, mean ± se, n = 6, multi-factorial ANOVA F(1,10) = 0.96, p = 0.35) or ML (contralateral WT: 8.6±0.9%, contralateral KO: 6.7±1.4%, mean ± se, n = 6, multi-factorial ANOVA F(1,10) = 1.228, p = 0.283; ipsilateral WT: 6.7±0.7%, ipsilateral KO: 4.5±0.8%, mean ± se, n = 6, multi-factorial ANOVA F(1,10) = 4.878, p = 0.052) axes did not reach statistical significance between WTs and KOs, the ratio of the RC and ML axes of the TZs (see Methods for definition) revealed a marked difference between the groups ( Fig. 6J ).

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