ftn-1 RNAi caused a slight reduction in daf-2 t -BOOH resistance, although this did not quite reach statistical significance ( p = 0.06, Fig. 3 F, Table S11 ).
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Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.
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Consistent with this, ftn-1(0) enhanced the Daf-c phenotype, increasing dauer formation at 23 °C from 6% to 23%, although this difference did not reach statistical significance, likely due to the typically high variation between individual Daf-c assays ( p = 0.12) ( Table S14 ).