Assessment of gene expression in HNSCC tumor tissues Vs normal mucosa controls Since only MAGEB2 showed near statistical significance for promoter demethylation in tumors we proceeded to assess if promoter demethylation of MAGEB2 is associated with tumor specific increased MAGEB2 gene expression.
← all excerpts
MAGEB2 is activated by promoter demethylation in head and neck squamous cell carcinoma.
2
—
—
The sentences
We assayed bisulfite extracted DNA from 76 HNSCC tumor tissues and 17 normal mucosa samples for MAGEB2 , KBGP/XK , DEAD/DDX43 which were found according to the preliminary BSS to be the most highly significant and showed high upfold expression values in AZA treated OKF6-T1 cell line ( Figure 3 , Table S6 ).