showed a trendP = 0.179
7 Although there was no statistical significance compared to placebo, the median overall survival showed a trend toward favoring zoledronic acid (295 days for the 4 mg zoledronic acid group vs 216 days for the placebo group; P = 0.179). 7 These results suggest that zoledronic acid not only decreases SREs, but also improves survival in patients with bone metastatic RCC.