Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies.

BMC Med Genet · 2012 · PMC3459788 · PMID 22943282

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showed a trendno p-value reported

Cumulative meta-analysis showed a trend of inverse association between C677T variant and ALL risk as evidence accumulated.

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marginally significantno p-value reported

Marginally significant inverse association was observed in allele contrast, recessive model and additive model (allele contrast: OR RE =0.91, 95% CI: 0.83-0.99; recessive model: OR FE = 0.86, 95% CI: 0.77-0.96; additive model: OR RE =0.80, 95% CI: 0.68-0.95; Figure 2 A).

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