Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53.

Since Mdm2 heterozygosity greatly delays tumor development in Arf -null mice that have both alleles of p53 , the difference in mean survival between p53+/+ and the p53+/− Arf -null Mdm2+/− mice was much larger than their Mdm2 wild-type counterparts and quite significant (p<0.0001, log-rank test; Fig. 2B , Table 1 ).

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