Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate.

PLoS One · 2012 · PMC3465278 · PMID 23071661

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showed a trendno p-value reported

While levels of expression of both anti-apoptosis gene Bcl-2 and pro-apoptosis gene Bax were not affected by treatments (data not shown), expression of both death receptor Fas and its ligand (Fas-L) showed a trend of up-regulation in MTX-treated rats, which was not seen in rats receiving supplementary FA treatment ( Fig. 3E & 3F ) .

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