The FSH-inhibin axis in prader-willi syndrome: heterogeneity of gonadal dysfunction.

Analysis of FSH and INB levels in the groups we defined, revealed highly significant differences among the 4 groups for both males ( P < 0.0001, ANOVA), and females ( P < 0.0001 and P < 0.001 for FSH and INB respectively) (Figure 1 ), as expected for the study design.

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Mean age, the genetic diagnoses, height, weight and BMI, as well as pubertal staging were similar within the groups, except for breast development in the females (P = 0.04) and pubic hair Tanner stage in the males (P = 0.04); however the differences did not reach statistical significance after Bonferroni correction.

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