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Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons.

Mol Neurodegener · 2012 · PMC3472284 · PMID 22973882

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We found that only 1-deoxySa significantly reduced the number of neuritic branches and outgrowths per DA neuron at concentrations as low as 0.5 μM (Figure 10 ); a trend towards compromising DA neuron viability was also evident but it did not reach statistical significance.

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