A comparison of diabetic smokers and non-smokers who undergo lower extremity amputation: a retrospective review of 112 patients.

Diabet Foot Ankle · 2012 · PMC3474996 · PMID 23082237

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an increasing trendno p-value reported

The higher amount of smoking in pack years followed an increasing trend of more proximal amputations as well.

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a significant trendno p-value reported

There was a significant trend toward diabetic smokers requiring a more proximal amputation than non-smoking diabetics.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.