Differing roles for TCF4 and COL8A2 in central corneal thickness and fuchs endothelial corneal dystrophy.

PLoS One · 2012 · PMC3479099 · PMID 23110055

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 4.8×10 −25actually significant

Association of FECD grade with TCF4 was highly significant (OR = 6.01 at rs613872; p = 4.8×10 −25 ), and remained significant when adjusted for changes in CCT (OR = 4.84; p = 2.2×10 −16 ).

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nominally significantno p-value reported

We observed two other nominally significant associations with the binary FECD trait, one SNP each in pituitary homeobox 2 ( PITX2 ) (rs17554590) and autogenous vein graft remodeling associated protein 8 ( AVGR8 ) (rs1034200), with p values of 0.028 and 0.015, respectively, for FECD status adjusted for CCT ( Table 3 and Table S1 ).

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