Exosomal cell-to-cell transmission of alpha synuclein oligomers.

We extended these findings to primary neurons and observed an increase in the αsyn oligomer signal in the exosomal fraction from neurons treated with bafilomycin A1 and a decrease in the αsyn oligomer signal with rapamycin treatment in the exosomal fraction compared to DMSO control (Figure 6 E), although these effects did not reach statistical significance (p = 0.17), probably due to the fact that the yield of exosomes are significantly less from primary neuronal preparations resulting in barely detectable luciferase and an decrease in the signal/noise ratio.

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