Separate analysis for coronary heart disease yielded similar results (adjusted HR: 1.49, 95% CI: 1.10–2.02, P =0.01; and adjusted HR: 1.50, 95% CI: 1.11–2.04, P <0.01, respectively), and a borderline significant trend was observed for ischemic stroke (HR: 1.34, 95% CI: 0.95–1.89, P =0.08; and HR: 1.32, 95% CI: 0.94–1.84, P =0.11, respectively).
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High level of plasma estradiol as a new predictor of ischemic arterial disease in older postmenopausal women: the three-city cohort study.
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