The single T65S mutation generates brighter cyan fluorescent proteins with increased photostability and pH insensitivity.

PLoS One · 2012 · PMC3487735 · PMID 23133673

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quite significantno p-value reported

One or both of these interactions may thus have a quite significant influence on chromophore flexibility and photophysics.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.