Alu and LINE-1 methylation and lung function in the normative ageing study.

BMJ Open · 2012 · PMC3488751 · PMID 23075571

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Results In multivariable models adjusted for age, height, body mass index (BMI), pack-years of smoking, current smoking and race, Alu hypomethylation was associated with lower forced expiratory volume in 1 s (FEV 1 ) (β=28 ml per 1% change in Alu methylation, p=0.017) and showed a trend towards association with a lower forced vital capacity (FVC) (β=27 ml, p=0.06) and lower FEV 1 /FVC (β=0.3%, p=0.058).

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