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PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients.

Clinics (Sao Paulo) · 2012 · PMC3488987 · PMID 23184205

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Although the association between PIK3CA mutations and steroid hormone receptor status did not reach statistical significance, we observed a higher frequency of PIK3CA mutations in estrogen receptor-positive tumors compared with receptor–negative tumors, mainly in exon 9.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.