Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.

There was a borderline significant 1.7-fold increase in mean Errα mRNA levels (95% CI 0.99 to 2.49; p = 0.05).

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A similar tendency for mice microinjected with AAV2/10-FHA- Pgc-1α and treated with MPTP to turn towards the ipilateral side again did not quite reach statistical significance when analyzed by comparing AAV2/10-FHA- Pgc-1α to AAV2/10- mCherry microinjected mice (95% CI −9.0 to 0.46; p = 0.07), potentially due to statistical noise introduced by varying levels of MPTP toxicity between animals.

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A trend towards increased expression of Prdx5 after Pgc-1α overexpression and MPTP treatment did not reach statistical significance (95% CI 0.83 to 3.1; p = 0.08).

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SYBR-green quantitative PCR revealed that over-expression of Pgc-1α resulted in a significant down-regulation of Pitx3 to 0.25±0.11 from a 0.79±0.08 level of expression after mCherry ( Figure 5C , 95% CI 0.23 to 0.85; p = 0.003), a nonsignificant trend toward lower Nurr1 expression (0.47±0.14 from 0.93±0.18, a difference of 0.46±0.24; 95% CI −0.08 to 1.0; p = 0.08), and no loss of Lmx1b expression relative to mCherry microinjected SN (1.26±0.33 from 1.1±0.23, a difference of −0.17±0.39; 95% CI −1.07 to 0.73; p = 0.677).

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