Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy.

Although the differences of fasting insulin and HOMA index between patients with and without the T allele did not reach statistical significance, there were trends toward a lower fasting insulin level (7.5 vs .10.3 mg/dl; P = 0.07) and less insulin resistance (HOMA index >3.8; 6.8 vs . 21.7%; P = 0.09) in those with the T allele.

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For the C1431T polymorphism in PPARγ, while patients with the T allele (48.4%) had trends toward lower rate of hypertriglyceridemia, the borderline significance together with insignificant power did not support the protective effect of the T allele against development of hypertriglyceridemia.

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