The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study.

In premenopausal women bearing R230C genotypes, this effect showed a modest increase (β = 3.74%; P = 4.9×10 −6 ) as compared to R230R homozygous premenopausal women (β = 2.55%; P = 1.2×10 −13 ) ( Figure S1 , C and D), although the interaction did not reach statistical significance ( P = 0.121).

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Associations with other Metabolic Parameters To date, all reports assessing the effect of the ABCA1 /R230C variant on HDL-C concentrations including the present study have consistently shown highly significant associations with decreased HDL-C levels [13] – [17] .

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In addition, individuals with subclinical atherosclerosis showed a marginally significant decreased risk of premature CAD adjusting for age, gender and BMI (OR = 0.690, 95% CI: 0.486–0.979, P dom = 0.038 and OR = 0.719, 95% CI: 0.520–0.994, P add = 0.046).

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