Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low.

Moreover, although we have found a nominally significant interaction between the FTO polymorphism and the aggregate score and folate intake in determining fasting plasma glucose concentrations, we cannot rule out the possibility that, as this is a secondary hypothesis and we have not corrected the P-values for multiple comparisons, the association obtained represents a false positive result.

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