The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs.

PLoS One · 2012 · PMC3496671 · PMID 23152905

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did not reach statistical significanceno p-value reported

In line with the results for GR transactivation, electrophysiological experiments revealed a tendency for endiandrin A to enhance ENaC-mediated Na + absorption after 48 hours (0.29±0.06 μA/cm 2 ), but again this did not reach statistical significance ( Fig.

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