We observed a decrease in the number of serotonin-positive fibres below the lesion level in the lumbar spinal cord of AM281-, AM630- and AM281/AM630-treated rats, although in the case of AM281-treated animals the changes failed to reach statistical significance (p = 0.06; Figure 8 ).
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Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.
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