Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT Study.

group; though the difference did not reach statistical significance in the lower heart rate group, there was no significant interaction ( P = 0.069) for the groups with the lower and higher heart rates for the hospitalization outcome.] Hospitalizations for any cause (2661 vs. 3110 events, IRR = 0.85, 95% CI, 0.78–0.94, P = 0.001) and cardiovascular hospitalizations (1909 vs. 2272 events, IRR = 0.84, 95% CI, 0.76–0.94, P = 0.002) were also less frequent with ivabradine than with placebo.

also in 111,027 other papers