Instead, pretreatment with either WM or Gö6976 prevented the increase in JNK2 phosphorylation induced by E 2 17G; although a clear trend towards prevention of JNK1 phosphorylation was also observed, this prevention only achieved statistical significance for Gö6976.
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ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K.
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