Similar to results obtained from xenograft and allograft models, here we observed that Elf5-KO/Neu transgenic mice displayed a clear trend of increased lung metastasis incidence ( Fig. 8b ), as well as significantly increased numbers of lung metastasis nodules ( Fig. 8c ) and greater lung lesion surface area ( Fig. 8d, e ) as compared to their WT/Neu counterparts.
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Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.
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