Human-specific histone methylation signatures at transcription start sites in prefrontal neurons.

sapiens -specific alleles ( neu HP compared to control peaks) showed a strong trend toward significant ( p = 0.067) for the Denisova, and reached the level of significance ( p = 0.034) for the Neanderthal genome (based on permutation test with 10,000 simulations [60] ).

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There were more than 245 (163) from the total of 410 HP spaced less than 1 (or 0.5) Mb apart, which is a highly significant, 2- (or 3-) fold enrichment compared to random distribution within the total pool of 34,639 peaks ( Figure 1C ; Text S1 ).

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