Overall, a lower percentage of patients on combination therapy experienced any asthma exacerbation (20.0%) compared to those administered the monotherapies (23.9% on fluticasone; 28.4% on formoterol) or placebo (32.4%), although the differences did not reach statistical significance.
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Safety and efficacy of fluticasone/formoterol combination therapy in adolescent and adult patients with mild-to-moderate asthma: a randomised controlled trial.
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