The effect of sulindac, a non-steroidal anti-inflammatory drug, attenuates inflammation and fibrosis in a mouse model of chronic pancreatitis.

Although the decrease of TGF-β and PDGF-β mRNA expression in caerulein induced chronic pancreatitis mice fed with sulindac diet did not reach statistical significance, the protein expression of TGF-β and PDGF-β were upregulated in chronic pancreatitis mice and sulindac treatment significantly decreased TGF-β and PDGF-β expression at the protein level.

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