Genetic polymorphisms of the dopamine and serotonin systems modulate the neurophysiological response to feedback and risk taking in healthy humans.

Cogn Affect Behav Neurosci · 2012 · PMC3505534 · PMID 22810728

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0640

boldest claim

The sentences

borderline significantp = .059so close (0.05 < p ≤ 0.1)

However, there was a significant effect of COMT genotype [ F (5.7, 155.16) = 3.18, p < .01, η 2 = .11] and a borderline significant effect of DAT1 genotype [ F (2.86, 166.02) = 2.57, p = .059, η 2 = .04] on changes in risk-taking behavior during the task. 5HTTLPR genotype was not significantly related to changes in risk-taking behavior throughout the task ( F < 1).

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marginally significantp = .064so close (0.05 < p ≤ 0.1)

For the percentage of risky choices following losses, we found a marginally significant effect of DAT1 genotype [ F (1, 58) = 3.56, p = .064, η 2 = .06], showing a tendency for more risk taking in 9R-carriers of DAT1, but no effect for the 5HTTLPR ( F < 1) or COMT val158met ( F < 1) genotype.

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showed a trendno p-value reported

As such, DAT1 genotype showed a trend-level association with risk taking directly after a loss was encountered, suggesting trial-by-trial behavioral adjustments.

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