The NP 311–325 CD4 T cell response in IL-7Rα 449F cells also showed a trend towards impairment, but this was not a significant difference ( Figure S4 ), perhaps due to the lack of a robust response in WT CD4 T cells in these chimeric mice.
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Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus.
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