Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation.

In the synaptoneurosomal fraction, similarly to what was found with RU486, compared to either naïve or trained rats injected with IgG, anti–BDNF significantly lowered the levels of pERK1/2 and pPLCγ without affecting those of ERK1/2 and PLCγ, and resulted in a strong trend toward a decrease, although not significant, of pAkt without changing Akt ( Fig. 4a and Supplementary Table 4 ).

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